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The mission of the Eastern Band of Cherokee Indians Medical Institutional Review Board (MIRB) is to protect the Tribe and its members, to ensure a mutual and
beneficial partnership between the
Cherokee people and researchers, and to
ensure that all health-related research
activities respect, promote, and benefit
the health of EBCI Tribal members.
The EBCI Medical Institutional
Review Board was founded in
2000 by Tribal Resolution (Resolution
No. 187 ) as a sister IRB to the
EBCI Cultural Institutional Review
Board (CIRB) to assure expertise in
review and assessment of health-related
research proposals. The MIRB
comprises nine medical, public health,
behavioral health, legal, cultural, and
community representatives with
experience in evaluation of research,
and the membership is always majority
enrolled American Indian/Alaska
Native. The MIRB is housed in the
Public Health and Human Services
Division (PHHS) and supported by the
Secretary of PHHS. The MIRB
maintains registration with the US
Department of Health and Human
Services Office for Human Research
Protections (US DHHS OHRP), and is
compliant with US 45 CFR.
WHY EBCI HAS AN INSTITUTIONAL REVIEW BOARD
For many generations, research has
been conducted on Native populations
with varying regard for their
autonomy, sovereignty, safety, privacy,
and benefit, and often without their
participation or proper permission.
There have been instances of profound
damage to Tribal cultures and
individuals as a result of research
performed by outside entities. The
establishment of Tribal IRBs is a
powerful means to bring the evaluation
and approval process for research
requests into the hands of those who
will most benefit from, or be harmed
by, these requests. The Eastern Band
of Cherokee Indians has complete and
final say over any health-related or
cultural research proposals and their
results performed in the EBCI
community — that is, on Tribal lands or
on any member of the Tribal
community — to protect our people and
lands and to assure that any research
performed has applicability to EBCI
and potential benefits to the
RESEARCH APPROVAL PROCESS
The MIRB meets on an ad hoc basis to
review research protocol submissions.
Please be aware
that the entire approval process takes a
minimum of one month and may take
up to five months. Because of the
necessity to submit a Resolution and present a proposal to Tribal
Government, there is no “fast track”
process for proposal approval.
No research may be conducted
on EBCI Tribal Lands without
explicit approval by the EBCI
Cultural or Medical IRB and a
If any member of the Tribal community knows of any research being conducted on Tribal lands that has not been approved by the MIRB or the CIRB, please contact us immediately at firstname.lastname@example.org.
To reach the EBCI Cultural Institutional Review Board, contact TJ Holland at email@example.com or 828-346-6898.
CONTINUING REVIEW OF RESEARCH
MIRB requires each researcher to provide a review of their proposal‘s progress every 12 months at minimum from the date of approval. Also, the MIRB requires that researchers submit a copy of manuscripts or publications that result from the research proposal before they are published. If the research project has any adverse results, the researcher must report these to the MIRB immediately.
EBCI MIRB: IMPORTANT DOCUMENTS
The following list comprises documents that are important to the submission process. Please review the Process Flow Chart and Instructions for Protocol Submission before completing the protocol submission, and review the Informed Consent Checklist before submitting an informed consent form.
• EBCI Medical IRB Process Flow Chart
• MIRB Protocol Submission Form
• EBCI Protocols with Minors Review Form
• MIRB Instructions for Protocol Submission
• MIRB Informed Consent (IC) Checklist
EBCI RESEARCH PROJECT RESULTS: WHAT DID THIS RESEARCH SHOW?
As the MIRB receives reports from researchers, a summary of the research project will appear here.